SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73
نویسندگان
چکیده
منابع مشابه
OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.
NANOG, OCT4 and SOX2 form the core network of transcription factors supporting embryonic stem (ES) cell self-renewal. While OCT4 and SOX2 expression is relatively uniform, ES cells fluctuate between states of high NANOG expression possessing high self-renewal efficiency, and low NANOG expression exhibiting increased differentiation propensity. NANOG, OCT4 and SOX2 are currently considered to ac...
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Article history: Received: .................. Accepted: ................... Available online: ........ ZJRMS 2015 Sep; X(X): XX-XX Background: Genes are involved in the control of stem cell self-renewal as a new class of molecular markers of cancer. In this study, the expression of Oct4, Nanog and Sox2 in cell lines MIA Paca-2, PA-TU-8902 and AsPC-1 and pancreatic cancer tissue were examined. M...
متن کاملgene expression analysis of sox2, nanog, klf4, oct4, and rex1 genes in cord blood mononuclear cells treated with external stresses
background: induced pluripotent stem cells (ipscs) can be obtained from autologous cells for therapeutic purposes. so, far, many studies have been done to produce induced pluripotent cells by transferring specific pluripotency genes using different methods. in this study, pluripotency gene expression induced by external stresses was assessed in cord blood mononuclear cells. methods: in this exp...
متن کاملReprogramming by cytosolic extract of human embryonic stem cells improves dopaminergic differentiation potential of human adipose tissue-derived stem cells
The extract of pluripotent stem cells induces dedifferentiation of somatic cells with restricted plasticity. In this study, we used the extract of human embryonic stem cells (hESC) to dedifferentiate adipose tissue-derived stem cells (ADSCs) and examined the impact of this reprogramming event on dopaminergic differentiation of the cells. For this purpose, cytoplasmic extract of ESCs was prepare...
متن کاملExpression and role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epithelium.
OBJECTIVES To explore the role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epithelium. MATERIALS AND METHODS An ex vivo model of rat tracheal epithelial regeneration using 5-fluorouracil (5-FU) was developed, to induce injury. Expression levels of Oct3/4, Nanog and Sox2 were examined using Western blot analysis, RT-PCR or microscopically observed immunofluorescence, and cell mor...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2016
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2016.09.008